منابع مشابه
Retinoic Acid Signaling Organizes Endodermal Organ Specification along the Entire Antero-Posterior Axis
BACKGROUND Endoderm organ primordia become specified between gastrulation and gut tube folding in Amniotes. Although the requirement for RA signaling for the development of a few individual endoderm organs has been established a systematic assessment of its activity along the entire antero-posterior axis has not been performed in this germ layer. METHODOLOGY/PRINCIPAL FINDINGS RA is synthesiz...
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BACKGROUND During Drosophila oogenesis a membranous organelle called the fusome has a key function in the establishment of oocyte fate and polarity, ultimately leading to the establishment of the major body axes of the animal. The fusome is necessary for the microtubule-driven restriction of markers of oocyte fate to the oocyte, but the mechanism by which the fusome organizes the microtubules i...
متن کاملGeminin organizes the molecular platform to balance cellular proliferation and differentiation.
Geminin was originally identified as an inhibitor of replication initiation, but is now known to play multiple roles in several fundamental cellular processes including proliferation, differentiation, development and transcriptional regulation. Recently, the functional properties of geminin have been further characterized by identifying geminin binding partners. To gain a broader molecular view...
متن کاملThe roof plate regulates cerebellar cell-type specification and proliferation.
During embryogenesis, the isthmic organizer, a well-described signaling center at the junction of the mid-hindbrain, establishes the cerebellar territory along the anterior/posterior axis of the neural tube. Mechanisms specifying distinct populations within the early cerebellar anlage are less defined. Using a newly developed gene expression map of the early cerebellar anlage, we demonstrate th...
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Early endosomes (EEs) mediate protein sorting, and their cytoskeleton-dependent motility supports long-distance signaling in neurons. Here, we report an unexpected role of EE motility in distributing the translation machinery in a fungal model system. We visualize ribosomal subunit proteins and show that the large subunits diffused slowly throughout the cytoplasm (Dc,60S = 0.311 µm(2)/s), where...
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ژورنال
عنوان ژورنال: Genome Biology
سال: 2003
ISSN: 1465-6906
DOI: 10.1186/gb-spotlight-20030711-01